Palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides

• Tao Fan,
• Wei-Dong Meng and
• Xingang Zhang

Beilstein J. Org. Chem. 2017, 13, 2610–2616, doi:10.3762/bjoc.13.258

• , Shanghai 200032, China 10.3762/bjoc.13.258 Abstract An efficient palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides has been developed. The reaction proceeds under mild reaction conditions with high efficiency and excellent functional group tolerance, even towards

• formyl and hydroxy groups. Preliminary mechanistic studies reveal that a secondary trifluoromethylated alkyl radical is involved in the reaction. Keywords: alkenes; cross-coupling; Heck-type reaction; palladium; secondary trifluoromethylated alkyl bromides; Introduction With the increasing number of

• fluoroalkylated allylic compounds can serve as a versatile building block for the synthesis of complex fluorinated molecules [36][37]. Herein, we describe a palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides. The reaction proceeds under mild reaction conditions with broad